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Grant CRF-1 Controlled Rate Freezer CRF-1 Controlled Rate Freezer

Condition Used
Stock Number 51136
This listing is for a Grant Controlled Rate Freezer - CRF-1


The unit is in full working condition and is ready for immediate release


Product Overview:
The CRF-1 Liquid Nitrogen-Free Controlled Rate Freezer is designed for precision-controlled freezing and cryopreservation of biological samples, such as embryos, stem cells, mammalian cells, spermatozoa, antibodies, tissue sections, and rodent organs. Unlike conventional liquid nitrogen-based freezers, the CRF-1 is liquid nitrogen and cryogen-free, eliminating contamination risks and making it suitable for use in cleanrooms and barrier facilities. It offers superior performance in terms of cell viability post-freezing and poses no fire hazard, unlike alcohol-based systems.


The CRF-1 allows for highly accurate, reproducible, and controlled freezing rates, crucial for the cryopreservation of biological samples, ensuring optimal recovery upon thawing.


Key Features:
Cryogen-Free Design: The CRF-1 is free from liquid nitrogen and alcohol, offering a safer, cleaner alternative to traditional freezing methods. No contamination risk, making it ideal for use in sterile environments.

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Precise Cooling Control: The cooling rate is accurately controlled, especially for the critical nucleation/seeding phase, which ensures consistent and optimal recovery of cells.
Wide Temperature Range: Capable of cooling down to -100°C with straws, offering a broad application range for biological cryopreservation.
Simple Operation: The CRF-1 operates with or without a PC, and it can log data via PC software. Cooling profiles are displayed directly and can be customized.
High Versatility: Compatible with cryovials, straws, bags, microplates, and Matrix-96-well block plates, allowing for research across multiple areas like stem cell research, transgenic embryos, mammalian cells, and more.
Low Operational Costs: The CRF-1 runs at approximately 1% of the cost of liquid nitrogen-based freezing systems.
Safety Features: Includes an optional Un-interruptible Power Supply (UPS) for complete cycle continuation in case of power failure.
Compact Quiet: Fits neatly on a bench-top and operates quietly, making it suitable for laboratory settings.


Main Applications:
Transgenic embryos research
Stem cell research
Clinical and research samples like lymphocytes and tissue cell lines
Mammalian cell preservation (e.g., cardiomyocytes, adipose, liver, muscle)
Cord blood-derived stem cells
Adherent cells and stem cells in microplates
Cell suspensions in numbered/barcoded arrays
Robotic integration for high-throughput applications
Veterinarian IVF applications


Technical Specifications:
Dimensions (w x d x h): 264 x 367 x 445 mm
Weight: 9.8 kg
Max Plate Temperature: 30°C
Min Plate Temperature: -80°C (standard) or -100°C (dependent on model)
Temperature Accuracy: ±0.5°C
Temperature Stability: ±0.1°C
Temperature Uniformity: ±1.0°C
Max Cooling Rate: 10°C/min
Max Temperature Stabilization Time: 5 minutes
Key Benefits:
Accurate and Reproducible Cooling Rates: Ensures controlled freezing rates and precise sample temperature management.
Customizable Cooling Profiles: Choose from linear and non-linear profiles, or create your own tailored profile.
No Cryogen or Liquid Nitrogen: Ideal for reducing contamination risk and the cost of liquid nitrogen.
Low Running Costs: Estimated to cost only 1% of traditional liquid nitrogen-controlled freezing methods.
End-of-Cycle Cooling Stability: Maintains a steady